Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma

Background/Aim: Carbohydrate antigen 19-9 (CA19-9) is a well-established poor prognostic marker in intrahepatic cholangiocarcinoma (IHCC). Previous studies have implicated a link between hypoxia and CA19-9 in various cancers, and our prior work has demonstrated a correlation between HDAC1 and HIF-1α in IHCC. This study aims to investigate the expression of CA19-9 and its relationship with HIF-1α and HDAC1 in IHCC.
Patients and Methods: A total of 62 IHCC patients who underwent primary hepatectomy at our institution were included in this study. Clinicopathological data were collected and analyzed. Immunohistochemical analysis was performed to assess the expression levels of HIF-1α and HDAC1 in tumor specimens, with quantitative evaluation.
Results: Elevated preoperative serum CA19-9 levels were associated Citarinostat with clinicopathological features indicative of tumor progression. High serum CA19-9 levels correlated with poorer overall survival and recurrence-free survival. Both univariate and multivariate analyses identified high CA19-9 as an independent poor prognostic factor for IHCC. Furthermore, serum CA19-9 levels were significantly correlated with the expression of both HIF-1α and HDAC1.
Conclusion: Elevated serum CA19-9 levels serve as an independent poor prognostic factor for overall survival in IHCC and are closely correlated with the expression of HIF-1α and HDAC1.